Francesco Fratini inizia ad 8 anni lo studio dello strumento (trumpet). Studia con i maestri Salvatore Catania e Franco Vasselli, Giampaolo Casati, Pietro Tonolo, Stefano Zenni, Marco Tamburini, Claudio Corvini, Enrico Rava, Gianluigi Trovesi. Nel gennaio 2009, ancora diciottenne viene chiamato da Enrico Rava a far parte del suo ensemble, a fianco di Daniele Tittarelli, Gianluca Petrella, Giovanni Guidi, Gianluigi Trovesi, Dan Kinzelman e Stefano Senni.
In September 2010 he moved to New York where, thanks to a four-year scholarship, he attended the courses of the New School For Jazz and Contemporary Music. During those five years in New York, he had the opportunity to study under the guidance of teachers such as Reggie Workman, George Cables, Aaron Goldberg, Steve Cardenas, Jimmy Owens, Andrew Cyrille, Laurie Frink, Ambrose Akimounsire, Avishai Cohen, Kirk Nurock, Doug Weiss, Marcus Printup, Jane Ira Bloom. He also performed at various New York clubs and festivals alongside musicians such as Austin Peralta, Chad Lefickofitz Brown, Alexander Claffy, Matt Chalk, Kyle Poole and Daniel Dor.
In December 2014 he graduated at The New School, earning a Bachelor of Fine Arts in Jazz and Contemporary Music.
In January 2015 he returned to Rome to resume an intense concert activity throughout Italy alongside musicians such as Pietro Lussu, Daniele Tittarelli, Rosario Giuliani, Danilo Rea, Fabio Zeppetella, Rosario Bonaccorso, Alessandro Lanzoni, Camilla Battaglia, Simone Graziano, Ares Tavolazzi, Mario Raja, Paolo Damiani, Bruno Biriaco, Mario Corvini, Domenico Sanna, Alessandro Lanzoni, Enrico Zanisi, Daniele Tittarelli, Francesco Diodati, Francesco Ponticelli , Giovanni Guidi, Fabrizio Sferra, Massimo Morganti, Marco Valeri, Enrico Morello, Luca Bulgarelli, Cristiano Arcelli and many others.
In March 2016 he graduated in Trumpet Jazz with honors at the Santa Cecilia Conservatory in Rome.
In recent years, he has been able to perform abroad, in Montreal and New York with the Francois Russeau Big Band, in Bern with Or Bareket Quartet, in Telaviv, Israel with the Michael Rosen Quartet, in Algeria in Constantine with Marta High, in Finland with Kurry Luthala Quartet in Helsinky, in Ryadh and Jeddah in Saudi Arabia and in Tiblisi in Georgia with the Paolo Damiani New Band , again in Tiblisi with the Nicola di Tommaso Quartet, in Berlin with Ugo Alunni Quartet.
He is a permanent member of the "Umbria Jazz Orchestra" and the Nazionale Jazz Giovani Talenti (ONJT)(National Jazz Youth Talents Orchestra) with which he performs in the prestigious contexts of the Teatro Piccolo in Milan, the Roman Theater of Fiesole in Florence, the Auditorium Parco della Musica and the Casa del Jazz in Rome, Prix Italia in Capri and many others.
Since 2016 he has been carrying on a quartet under his name, composed by Domenico Sanna, Luca Fattorini and Matteo Bultrini, with whom he is close to the release of his first album "The Best Of All Possible Worlds" for Jando Music.