Marcello Sirignano si diploma in violino nel 1988 e in jazz nel 2005 presso il Conservatorio di Musica S. Cecilia in Roma sotto la guida dei maestri Bruno Mollo, Mila Costisella e Paolo Damiani.
After graduating on violin, he continued to study with the masters Franco Tamponi and Pavel Vernikov and participated in several chamber music courses with the masters Marco Lenzi and Paolo Centurioni.
From 1990 he began studying jazz with Massimo Fedeli and took part in the courses of the Berklee College of Music held in Perugia.
Already as a student, he began an intense chamber and orchestral concert activity collaborating with various institutions and musical seasons including: Sanremo Symphony Orchestra, Lazio Regional Orchestra, Gonfalone Orchestra, C.I.M.A., Extravaganza, University Concert Institution.
At the same time, he participated in numerous recordings sessions of CD's and soundtracks both as a solo and orchestral instrumentalist and as an arranger and conductor.
In addition, he participated as a violinist in theatrical performances and television broadcasts.
Come jazzista partecipa a concerti e incisioni collaborando con i più importanti musicisti italiani tra i quali: Enzo Pietropaoli, Roberto Gatto, Giovannni Tommaso, Bruno Tommaso, Tommaso Vittorini, Pietro Tonolo, Danilo Rea, Gabriele Mirabassi, Xavier Girotto, Massimo Nunzi, Battista Lena, Stefano Di Battista, Salvatore Bonafede, Paolo Damiani, Maurizio Gianmarco, Giovanni Lo Cascio, Checco Marini.
In April 2006, he released his first album of original compositions with the participation of Stefano Di Battista and Danilo Rea published by Camjazz label and later distributed all over the world.
He is currently a member of the Danilo Rea Quintet and the Santa Cecilia Jazz Quartet with Paolo Damiani and takes part at the teaching board at the Saint Louis College of Music in Rome holding the jazz violin course.