Sandro Mambella inizia lo studio del pianoforte all’età di quattro anni e frequenta le scuole medie presso il Conservatorio “S.Cecilia” in Roma . Nel ’93 avvia lo studio del pianoforte jazz con Fabrizio Pieroni e frequenta le Umbria Jazz Clinics (1994).
Nel ‘96 inizia gli studi di composizione con Teresa Procaccini e prosegue quelli di pianoforte jazz con Ramberto Ciammarughi. Si diploma in Pianoforte presso il Conservatorio “F. Morlacchi” di Perugia, con il M° Riccardo Marini nel 1998 e l’anno successivo frequenta il Corso di Perfezionamento Jazz presso l’Accademia Romana di Musica con Fabrizio Sferra, Maurizio Giammarco, Danilo Rea, Fabio Zeppetella and Giovanni Tommaso.
Then, in 2002, he obtained a diploma in Jazz Music at the Santa Cecilia Conservatory in Rome, under the guidance of M° Bruno Tommaso. The following year, he enrolled in the course of experimental composition at the N. Piccinni Conservatory in Bari directed by M° Riccardo Santoboni.
His artistic experiences began in 1994 with the participation in the concert for fifty pianos "Primi Piani" held in Piazza del Popolo, in Rome, on December 31st under the direction of Bruno Tommaso and, among others, with Danilo Rea, Riccardo Fassi, Stefano Sabatini, Antonello Salis. He also took part in radio and television broadcasts such as "Stasera a Via Asiago, 10" directed by Umberto Broccoli (Radiorai 2) and "Bianco e Nero" (Rai 2).
In 2001 he formed the "Sandro Mambella Quartet" with which he participated in various musical exhibitions including the 8th edition of "Concerti sotto le stelle" in Pescara and the "XV Rassegna Concertistica" by Caramanico Terme. His teaching path began in 1993. Since 1998 he has been a music consultant at Mediaset networks.
In between July and August of the same year, he was assistant and collaborator of Mario Raja at the seminars of Siena Jazz for the laboratory orchestra.
Since 2010, he held several music activities also as organist in various musical fields, from jazz, rock and soul. Among the various formations: an organ trio on the music of guitarist John McLaughlin and the rock group of the actor Pasquale Petrolo, aka Lillo.